How secure is a hardened Google Chrome EMET 5 1 setup against browser-based threats for a small business

Question

I’ve set up a Google Chrome browser with added hardening configurations and enabled EMET 5.1 (Enhanced Mitigation Experience Toolkit) to protect against browser-based threats, but I’m not entirely sure how effective this combination is for a small business environment. Are there any specific vulnerabilities that this setup might still leave exposed? Can it effectively protect against zero-day threats or other sophisticated attacks commonly targeting small businesses?